It is used to relieve mild to moderate pain, including headaches, dental pain, osteoarthritis and rheumatoid. Mefenamic acid is the generic name of the drug, which is the name of the active component that has an effect on your body. Only select registry of toxic effects of chemical substances rtecs data is presented here. Pfizer inc believes that the information contained in this material safety data sheet is accurate, and while it is provided in good faith, it is without a warranty of any kind, expressed or implied. May 25, 2016 mefenamic acid is a potent inhibitor of prostaglandin synthesis in vitro. Mefenamic acid is rapidly absorbed after oral administration. You may also know it better by one of its brand names, mefic or ponstan, which are the names given to the medication made by each pharmaceutical company for marketing purposes. The concentration of mefenamic acid is determined using the previously prepared calibration curve using standard solution of. History of asthma, urticaria, or other allergictype reactions after taking aspirin or other nsaids.
On the other hand, mefenamic acid has high solubility in watermiscible organic solvent, namely ethanol 14. Mefenamic acid 61687 tokyo chemical industry uk ltd. Chemeo is only indexing the data, follow the source links to retrieve the latest data. Other companies are charging thousands of dollars to set up accounts and give you access to their msds online database.
Mefenamic acid is used to relieve mild to moderate pain, including menstrual pain pain that happens before or during a menstrual period. Halflife 5 times longer in preterm infants compared with adults. Nov 09, 2018 mefenamic acid is a nonsteroidal antiinflammatory drug nsaid. Feb 14, 2016 mefenamic acid has poor solubility in water of which range spanned from approximately 0,004 mgml 37 c to 0. Preparation and evaluation of methyl salicylate counter. Mefenamic acid is a nonsteroidal antiinflammatory drug. Health mefenamic acid capsules are contraindicated in the following patients. Mefenamic acid is a nonselective inhibitor of cox1 and cox2 that also potentiates activity at gabaa receptors. Mar 03, 2020 if you are 65 or older, use mefenamic acid with care. Sigmaaldrich offers a number of mefenamic acid products. Mefenamic acid ponstel is an oral drug used shortterm to treat pain, including menstrual cramps. M has cytotoxic effects on kb, saos2, and 21n cells, however, u87mg cells are resistant to mefenamic acid2. This goes back to normal when mefenamic acid is stopped. Find more compounds similar to mefenamic acid note.
Identification of the substancemixture and of the companyundertaking product name. Spectrophotometric assay of mefenamic acid in tablets using 1. Mefenamic acid is a white to greyishwhite, odorless, microcrystalline powder with a melting point of 230231c and water solubility of. End of safety data sheet eu einecs list 20051 australia aics. In patients with renal or hepatic impairment, clearance of metabolites may be decreased. The source is also providing more information like the publication year, authors and more. Mefenamic acid c15h15no2 cid 4044 structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities. Mefenamic acid medicinal forms bnf content published by. Nsaids like mefenamic acid may affect egg release ovulation in women. Mefenamic acid medicinal forms bnf content published by nice. The aim of this study was to analyse the clinical features of ma poisoning in domestic animals, since information on patterns of ma toxicosis is scarce. Mefenamic acid ingestion, usually in excess and over prolonged period is known to produce interstitial nephritis, or less commonly papillary necrosis, with acute renal failure 1. Chemical structure of mefenamic acid mefenamic acid is commonly used for the management of pain, fever and menstrual pain mefenamic acid decreases inflammation and uterine contractions by the inhibition of. Mefenamic acid is a nonsteroidal antiinflammatory agent, acting as a competitive inhibitor of hcox1, with ic50s of 40 nm and 3.
Flufenamic acid, mefenamic acid and niflumic acid inhibit. Although classed as a nonsteroidal antiinflammatory drug, its antiinflammatory properties are considered to be minor. Mefenamic acid is typically prescribed for oral administration. Mefenamic acid undergoes metabolism by cyp2c9 to 3hydroxymethyl mefenamic acid, and further oxidation to a. Extreme high moderate low section 1 chemical product and company identification product name mefenamic acid statement of hazardous nature considered a hazardous substance according to osha 29 cfr 1910.
It works by stopping the bodys production of a substance that causes pain, fever, and inflammation. Learn about side effects, warnings, dosage, and more. Assay preparation transfer about 100 mg of mefenamic acid, accurately weighed, to a 500ml volumetric flask, dissolve in and dilute with mobile phase to volume, and mix. Present eu einecs list 2005592 lactose mefenamic acid australia aics. Mefenamic acid is a potent inhibitor of prostaglandin synthesis in vitro. Pdf the bioavailability and pharmacokinetics of mefenamic. Mefenamic acid in plasma was assayed by high performance liquid chromatography.
Pdf molecular recognition and solubility of mefenamic acid. Huang and xu developed a fluorimetric method for analysis of some acid drugs by using pyronine to form a drugdye complex. A spectrophotometric method of assay of mefenamic acid in tablets involving, dissolving the tablet powder in 1,4dioxane and measuring the absorbance at 353. Dissolution profile of mefenamic acid solid dosage forms in. Mefenamic acid has been reported as being greater than 90% bound to albumin. In na 2 hpo 4 solution, mefenamic acid reacts with pyronine to form a complex which is soluble in chcl 3. Chromatographic system see chromatography 621 the liquid chromatograph is equipped with a 254nm detector and a 4. Mefenamic acid undergoes metabolism by cyp2c9 to 3hydroxymethyl mefenamic acid, and further oxidation to a 3carboxymefenamic acid may occur 3. Mefenamic acid capsules 78 weeks rat oral25 mgkgday noel kidney, gastrointestinal system rat oral ld50 740mgkg 1 years dog oral 200 mgkgday loael kidney, liver version. Each bluebanded, ivory capsule contains 250 mg of mefenamic acid for oral administration. M has cytotoxic effects on kb, saos2, and 21n cells, however, u87mg cells are resistant to mefenamic acid 2. Mefenamic acid dosing, indications, interactions, adverse. Stability indicating method for the determination of.
For details on the management of poisoning, see emergency treatment of poisoning, in particular, convulsions. Mefenamic acid drug bnfc content published by nice. Find out what health conditions may be a health risk when taken with mefenamic acid oral. The halfmaximal inhibitory ef fect is about 10 mefenamic acid investigated as a drug and reproductive effector, and tumorigen. Ponstel mefenamic acid is a member of the fenamate group of nonsteroidal antiinflammatory drugs nsaids.
Mefenamic acid is in a class of medications called nsaids. Mefenamic acid works by reducing hormones that cause inflammation and pain. Consider potential benefits and risks of mefenamic acid therapy as well as alternative therapies before initiating therapy with the drug. Ponstan capsules contain the active ingredient mefenamic acid 250 mg capsule. The mechanism of action of mefenamic acid is as a cyclooxygenase in more. The drug solubility would be enhanced by the emulgel formulation. Mefenamic acid is a fenamate nonsteroidal antiinflammatory drug nsaid that exhibits antiinflammatory, analgesic, neuroprotective, anticancer, and neuromodulatory activities.
Methyl salicylate was incorporated in some formulation which acts as counter irritant. The determination of mefenamic acid at trace level by fluorescence spectrometry was also reported by miller et al. Estimation and analysis of mefenamic acid suspension. Mefenamic acid is a nonsteroidal antiinflammatory drug nsaid. Mefenamic acid concentrations reached during therapy have produced in vivo effects. Mefenamic acid has important consequences in overdosage because it can cause convulsions, which if prolonged or recurrent, require treatment. The concentration of mefenamic acid is determined using the previously prepared calibration curve using standard solution of mefenamic acid in dioxane. Mefenamic acid ma is a fenamate nonsteroidal antiinflammatory drug nsaid which exhibits central nervous system cns toxicity in human overdose with seizures as a common manifestation. Aug 20, 2019 mefenamic acid oral capsule is a prescription drug used to treat mild to moderate pain and dysmenorrhea menstrual pain. Mefenamic acid works by reducing hormones that cause inflammation and pain in the body. N2,3xylyl2aminobenzoic acid n2,3xylylanthranilic acid catalog of chemical suppliers, buyers, custom synthesis companies and equipment manufacturers. Mefenamic acid oral capsule is a prescription drug used to treat mild to moderate pain and dysmenorrhea menstrual pain.
Mefenamic acid is a fenamate nonsteroidal antiinflammatory drug nsaid that exhibits antiinflammatory, analgesic, neuroprotective. Mefenamic acid side effects, dosage, interactions drugs. Material safety data sheet mefenamic acid sc205380 hazard alert code key. Sep 23, 2015 mefenamic acid ponstel is an oral drug used shortterm to treat pain, including menstrual cramps. Materials and methods the following materials were used in the study. Prostaglandins sensitize afferent nerves and potentiate the action of bradykinin in inducing pain in animal models. Hazardous combustion or decomposition products are expected. Mefenamic acid investigated as a drug and reproductive effector, and tumorigen. If you are 65 or older, use mefenamic acid with care. How to use mefenamic acid read the medication guide provided by your pharmacist before you start using mefenamic acid and.
Tolfenamic acid safety data sheet supersedes revision. See actual entry in rtecs for complete information. Mefenamic acid decreases inflammation and uterine contractions by a stillunknown mechanism. Mefenamic acid 61687 buy and find out price and availability, msds, properties of tcis high quality specialty chemicals. The bioavailability and pharmacokinetics of mefenamic acid was studied in alloxandiabetic rabbits. To minimize the potential risk of adverse cardiovascular and. Hazard identification material safety data sheet material mefenamic acid capsules usp, 250 mg. Webmd provides common contraindications for mefenamic acid oral.
Mefenamic acid is an aminobenzoic acid that is anthranilic acid in which one of the hydrogens attached to the nitrogen is replaced by a 2,3dimethylphenyl group. History of asthma, urticaria, or other allergictype reactions after taking aspirin or. Mefenamic acid capsules are contraindicated in the following patients. Your new online msds binder is a place for you to store the material safety data sheets you need to deploy. Mefenamic acid tablets acgih threshold limit value twa 10 mgm3 vietnam oel twas lithuania oel twa 5 mgm3 6 mgm3 5 mgm3 sweden oel twas 5 mgm3 lithuania oel twa talc nonasbestiform mefenamic acid 5 mgm3 acgih threshold limit value twa 2 mgm3 version.
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