Reactions secondary to the administration of nonprotein drugs are clinically similar to serum sickness reactions. Picture of skin diseases and problems serum sickness. Serum sickness what is it immunization of host human by heterologous nonhuman serum proteins caused by. An inflammatory response occurs that leads to joint, skin, and systemic manifestations.
The immune system reacts to medicines that contain proteins used to treat immune conditions. Serum sickness is a reaction that is similar to an allergy. Hypersensitity, and types of hypersensitivity i, ii, iii, iv. Degranulation cytolysis cytokine upregulation antigen presentation b cells. Differs from serum sickness in that it infrequently has associated proteinuria and lymphadenopathy. Serum sicknesslike reaction sslr is an uncommon adverse cutaneous drug eruption that. Serum sickness serum sickness is a type of allergic reaction that may occur 714 days after you have been given an anti serum or antivenom. Antigenantibofy complexes get deposited along the basement membranes of small vessels. A unique presentation of serum sickness from rabbit antithym. Ppt serum sickness powerpoint presentation free to.
Serum sickness presented by athit wutthisanwatthana, md. Serum sickness is a type iii hypersensitivity reaction that results from the injection of heterologous or foreign protein or serum. Set the unison voices to all have their unique waveform at once with the unison wt pos setting, or. Serum sickness is a condition that happens in reaction to certain medications. More detailed information about the symptoms, causes, and treatments of serum sickness is available below symptoms of serum sickness. Can present with serum sickness fever, arthritis, urticaria, angioedema associated with polyarteritis nodosa pan 11.
Serum sickness definition is an allergic reaction to the injection of foreign serum manifested by hives, swelling, eruption, arthritis, and fever. They may start sooner if you have had the medicine before. Serum sickness is characterized by rash, fever, arthralgia or arthritis. View an illustration of serum sickness and learn more about additional skin conditions.
Serum sickness is an unexpected reaction to some medicines. The reaction may take 3 10 hours after exposure to the antigen as in arhus reaction. View large image view hires image download powerpoint slide. Antigens causing immune complex mediated injury are. Penicillin is the most common cause of serum sickness. Classic serum sickness results from the formation of immune complexes due to immunization of a human host with a foreign protein. Serum sicknesslike reaction associated with mirabegron jaad. Prof dr dr ariyanto harsono spak 2difinition serum sickness is a hypersensitivity vasculitis due toforeign objects. Serum sickness symptoms, diagnosis, treatments and causes. What is serum sickness serum sickness is a selflimited allergic reaction following exposure to foreign proteins. Ppt hypersensitivity reactions powerpoint presentation. Serum sickness like reaction sslr is an uncommon adverse cutaneous drug eruption that mimics serum sickness ss. It can also react to antiserum, the liquid part of blood that contains antibodies given to a person to help protect them against germs or poisonous substances. Signs and symptoms itchy rash usually red with white wheals hives or urticaria, which occur in batches or clusters.
Follows the administration of foreign proteins or chemicals. Serum sicknesslike reaction associated with mirabegron. The syndrome was initially described in the early 1900s when it was seen in association with the use of horse serum containing diphtheria antitoxin. Serum sickness definition of serum sickness by merriam.
Medicines that can cause it include antibiotics like penicillin. Nice powerpoint template will be great choice for presentations on swine influenza, flu, influenza virus siv, h1n1, influenzalike illnesses, infectious diseases, epidemic, respiratory infections, virology, immune system, immunity, etc. The condition, known as serum sickness, is a type iii immune complex hypersensitivity reaction that results from the injection of foreign protein or serum. Urticarial, coalescing plaques on the lower legs of an adolescent with serum sickness. Our patient received antihistamines and systemic corticosteroids and the skin rash resolved after 2 weeks. It was first recognized as an entity in the early 1900s in patients who had received heterologous antisera, which was historically used to treat infectious diseases. Both conditions feature urticarial lesions, joint symptoms, and lymphadenopathy, but only ss manifests hypocomplementemia and renal involvement and is an immune complex hypersensitivity that is usually associated with parenteral nonhuman protein drugs. Serum sickness is not to be confused with a serum sicknesslike reaction, which results in a similar clinical presentation but does not involve. Serum sickness is an example of the type iii, or immune complexmediated, hypersensitivity disease.
Nice red medical powerpoint template with micropicture of blood cells on it will be great choice for presentations on hematology, hematological tests, blood research, diseases of the blood, hemopathy, hepatopathy, and the like. The adobe flash plugin is needed to view this content. Serum will let you stack a single oscillator to use up to 16 voices. Powerpoint is the worlds most popular presentation software which can let you create professional hypersensitivity and allergy powerpoint presentation easily and in no time. The illness developed a few weeks after administration of horse serum. Powerpoint presentation powerpoint presentation immunization immunization figure 17. Classical serum sickness is caused by the injection of heterologous serum proteins such as horse serum.
Is a protoype of systemic immune complex hypersensitivity reaction. Serum sickness what is it immunization of host human by heterologous nonhuman serum proteins caused by formation of immune complexes a diagnosis made clinically and one of exclusion. Nice red powerpoint template will be a good choice for presentations on aids, virus, blood, body fluids, blood tests, blood disease, hemopathy, etc. The symptoms typically occur one to two weeks after exposure to an offending. Often occurs within the first 1 to 3 weeks after initiation of the offending drug. Theyll give your presentations a professional, memorable appearance the kind of sophisticated look that todays audiences expect.
Serum sickness and serum sicknesslike reactions uptodate. They successfully employed intravenous injections of procaine hydrochloride to abolish the manifestations of serum sickness. Nice powerpoint template will be great choice for presentations on antivirus membrane, virus attack, infectious agents, viruses, virology, microbiology. Serum sickness is an illness caused by circulating immune complexes. Ppt serum sickness powerpoint presentation, free download id. Serum sickness serum sickness is the prototypic example of the gell and coombs type iii or immune complexmediated hypersensitivity disease table 1 2. Etiology which often is the cause of horse serum proteins,for example, is ads and ats. Symptoms may start 7 to 10 days after you take the medicine. Terminology serum sickness syndrome caused by immune reaction to a heterogenous or chimeric protein therapeutic serum sickness like reactions sslr related syndromes of rash, arthritis, and fever beginning several days to weeks following administration of other types of drugs or in association with some infections 30. The molecular size, charge, structure, amount, and valence of the antigen involved influence the type of immune complexes formed. Serum sickness symptoms include redness and itching at the injection site, rash, hives, joint paint, fever, and feeling unwell. Eichenfield, in comprehensive pediatric hospital medicine, 2007. Serum sickness in humans is a reaction to proteins in antiserum derived from a nonhuman animal source, occurring 510 days after exposure. The term serum sickness like reaction sslr is occasionally used to refer to similar illnesses that arise from the introduction of certain nonprotein substances, such.
Nice powerpoint template will be great choice for presentations on ovum, ova, reproductive cells, fertilization, fertility, insemination, ovulation, and the like. Each of the wavetable oscillators have a number of unison advanced parameters. Free download hypersensitivity and allergy powerpoint. The reaction requires the presence of the antigen, coincident with antibodies directed against the antigen, leading to the formation of antigenantibody or immune complexes. Winner of the standing ovation award for best powerpoint templates from presentations magazine.
More likely to occur during or following a second course of antibiotics particularly cefaclor. Identification and removal of the causative agent is the key, but note treatment may have been. We present a case of serum sicknesslike reaction in a pediatric patient with chronic urticaria treated with omalizumab. Worlds best powerpoint templates crystalgraphics offers more powerpoint templates than anyone else in the world, with over 4 million to choose from. This helps you give your presentation on hypersensitivity and allergy in a conference, a school lecture, a business proposal, in a webinar and business and professional representations. Serum sickness develops 7 to 10 days after initial exposure. It is a type of hypersensitivity, specifically immune complex hypersensitivity. Serum sickness is an immunecomplexmediated hypersensitivity reaction that classically presents with fever, rash, polyarthritis or polyarthralgias. Serum sickness like reactions refer to a constellation of symptoms clinically resembling classic serum sickness but typically caused by drugs, and less frequently by infection. Serum sickness occurs when the immune system has a delayed response to medications or antiserums. The key features of serum sickness and serum sickness like reactions sslrs are rash, fever and polyarthritis. They described an illness that developed in some patients after they were given horse serum antitoxin for diphtheria and scarlet fever. Ppt liver diseases powerpoint presentation free to download id.
Some vaccines, insect stings, or spider bites might also cause it. Serum sickness is an immunemediated hypersensitivity reaction due to the injection of nonhuman antitoxins that is characterized by rash, arthritis, and fever and commonly associated with other systemic features epidemiology of pediatric serum sickness. Prof dr dr ariyanto harsono spak 1serum sicknessprof dr dr ariyanto harsono spak 2. Serum sickness is considered a type iii hypersensitivity reaction. Serum sickness is a disease characterized by fever, arthralgia, skin eruptions, and edema which appears alter injection of a foreign serum or serum proteins and is dependent upon an immune response of the patient to the injected serum. The resulting immune complex of the patients antibodies bound to the foreign protein is deposited in small blood vessels and stimulates the complement cascade and hence an inflammatory reaction. Signs and symptoms of true serum sickness occur one to two weeks after first exposure, while sslrs usually develop after 5 to 10 days. Learn more about the rash it causes and its other symptoms. The recent report of state and wangensteen 1 was the first concerning the use of a drug having a satisfactorily specific therapeutic action in the treatment of serum sickness. The incidence of serum sickness and other immunemediated reactions to drugs or other antisera agents has been. Ppt hypersensitivity reactions powerpoint presentation free to download id. A unique presentation of serum sickness from rabbit antithymocyte globulin in a kidney transplant recipient. Serum sickness is sometimes called a type iii hypersensitivity reaction. Serum sickness is a type iii hypersensitivity reaction from the administration of foreign protein, serum or nonprotein medications.
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